A Common Disease with Suboptimal Therapy.
Allergic conjunctivitis has been estimated to affect 20 to 40% of the population worldwide, and is characterized by itchiness, redness, and excessive tear production. The disease is most often treated with antihistamines to diminish the allergic response.
Current Allergic conjunctivitis treatment challenges.
Despite the availability of treatments for allergic conjunctivitis, a significant number of patients do not respond to antihistamines, especially after the acute effects of the medication wear off. Many of these patients are then prescribed corticosteroids and other more potent drugs that may lead to a variety of ocular toxicities.
The Allergic conjunctivitis treatment potential of reproxalap.
Aldehydes are thought to mediate part of the allergic response as well as ocular redness. By trapping aldehydes, reproxalap represents a new therapeutic approach for the treatment of allergic conjunctivitis. In an animal model of ocular inflammation, reproxalap was effective in diminishing ocular redness, and the effect of reproxalap was equivalent to that observed with corticosteroids. In addition, reproxalap has shown potent effects in the reduction of swelling in a skin model of allergy. Finally, reproxalap leads to a down-regulation of key cytokines (protein mediators) of the allergic response.
We announced positive data from our Phase 2a and Phase 2b clinical trials of reproxalap ophthalmic solution in allergic conjunctivitis. The results indicate that reproxalap clinically improved ocular itching scores in patients with allergic conjunctivitis in an allergen challenge model.