Symptoms of Sjögren-Larsson Syndrome
The central nervous system (CNS) symptoms are cognitive developmental impairment, stiffness and tightness of the legs resulting in difficulty moving, and seizures. SLS patients also have eye problems such as glistening white dots in the eye and sensitivity to light. This is because the eyes are part of the CNS.
In addition, people with SLS have scaly, itchy, thickened skin, called ichthyosis. Healthy skin has a natural moisture barrier that holds water in. People with SLS have problems forming the skin’s natural moisture barrier, which results in water loss. SLS patients say that their itchy skin makes them constantly uncomfortable, as it affects most of the body surface. They often irritate their skin with scratching