Autoimmune / Inflammatory Disease

Immune-mediated systemic diseases, such as autoimmune disease, are generally chronic conditions characterized by excessive and misdirected inflammatory responses. In aggregate, autoimmune diseases and related systemic inflammatory disorders represent tens of millions of patients in the United States.

Given the complex pathophysiology of systemic immune-mediated disorders, many of which are caused by a variety of pro-inflammatory mediators, therapy often requires combinations of drugs with distinct mechanisms of action.

Because levels of RASP are generally observed to be elevated in autoimmune and inflammatory disease, we believe the potential therapeutic applicability of our RASP inhibitors is broad.