Pipeline + Disease Areas | Aldeyra Therapeutics Inc.

Aldeyra is dedicated to improving the lives of patients suffering from immune-mediated ocular and systemic diseases. We are advancing a broad pipeline of product candidates diversified by chemical composition, mechanism of action, and clinical indication.

Our clinical pipeline encompasses three distinct biological mechanisms of action: Reactive Aldehyde Species (RASP) inhibition, Dihydrofolate Reductase (DHFR) inhibition, and Chaperome (CHP) inhibition. The immunological activity of our product candidates may potentially lead to diminished levels of pathological inflammation via the down-regulation of immune cell activation or proliferation.

Ocular Diseases

Compound	Mechanism	Preclinical	Phase 1	Phase 2	Phase 3	Registration
Ocular Disease
Reproxalap Disease Area: Dry Eye Disease Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration
Reproxalap Disease Area: Allergic Conjunctivitis Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-2191 FDA Fast Track Designation Disease Area: Proliferative Vitreoretinopathy Mechanism: DHFR	DHFR	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-2191 Disease Area: Intraocular Lymphoma Mechanism: DHFR	DHFR	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-103/10X Disease Area: Retinal Disease Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration

Learn More about our ocular disease clinical pipeline

Systemic Diseases

Compound	Mechanism	Preclinical	Phase 1	Phase 2	Phase 3	Registration
Systemic Diseases
ADX-629 Disease Area: Cytokine Release Syndrome (COVID-19) Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-629 Disease Area: Allergy (Atopic Asthma) Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-629 Disease Area: Autoimmune Disease (Psoriasis) Mechanism: RASP	RASP	Preclinical	Phase 1	Phase 2	Phase 3	Registration
ADX-1612 Disease Area: Ovarian Cancer Mechanism: CHP Research Collaboration: Investigator-Sponsored Trial	CHP	Preclinical Research Collaboration: Investigator-Sponsored Trial	Phase 1	Phase 2	Phase 3	Registration
ADX-1612 Disease Area: SARS-CoV2 Antiviral (COVID-19) Mechanism: CHP	CHP	Preclinical	Phase 1	Phase 2	Phase 3	Registration

Learn More about our systemic disease clinical pipeline